Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver …
F Diraison, PH Moulin, M Beylot - Diabetes & metabolism, 2003 - Elsevier
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is frequently observed in insulin-
resistant subjects and can lead to liver fibrosis and cirrhosis. The abnormalities of lipid
metabolism behind this development of excess hepatic TG stores are poorly understood.
METHODS: To clarify these mechanisms we measured triglyceride secretion rate and the
contributions of hepatic lipogenesis and reesterification of non-esterified fatty acids (NEFA)
to this secretion in healthy subjects and in patients with clear evidence of NAFLD. All …
resistant subjects and can lead to liver fibrosis and cirrhosis. The abnormalities of lipid
metabolism behind this development of excess hepatic TG stores are poorly understood.
METHODS: To clarify these mechanisms we measured triglyceride secretion rate and the
contributions of hepatic lipogenesis and reesterification of non-esterified fatty acids (NEFA)
to this secretion in healthy subjects and in patients with clear evidence of NAFLD. All …