Apart from UCP1-based nonshivering thermogenesis in brown adipocytes, the identity of
thermogenic mechanisms that can be activated to reduce a positive energy balance is
largely unknown. To identify potentially useful mechanisms, we have analyzed physiological
and molecular mechanisms that enable mice, genetically deficient in UCP1 and sensitive to
acute exposure to the cold at 4° C, to adapt to long term exposure at 4° C. UCP1-deficient
mice that can adapt to the cold have increased oxygen consumption and show increased …