Macrophage polarization: reaching across the aisle?

MC Bosco - Journal of Allergy and Clinical Immunology, 2019 - jacionline.org
Macrophage polarization can influence the pathogenesis of many human diseases;
however, the transcriptional program regulating this process remains poorly characterized.
Gharib et al 1 highlight the high diversity of M1-to-M2 repolarization exerted by distinct M2
stimuli through transcriptome-based pathway analysis and provide a new approach to
phenotype human macrophages in clinically relevant disease states, such as cystic fibrosis
(CF) and asthma. An extensive literature documents the high versatility of macrophages …