Zero-inflated Poisson (ZIP) regression is a model for count data with excess zeros. It assumes that with probability p the only possible observation is 0, and with probability 1 – p, a Poisson(λ) random variable is observed. For example, when manufacturing equipment is properly aligned, defects may be nearly impossible. But when it is misaligned, defects may occur according to a Poisson(λ) distribution. Both the probability p of the perfect, zero defect state and the mean number of defects λ in the imperfect state may depend on covariates. Sometimes p and λ are unrelated; other times p is a simple function of λ such as p = l/(1 + λ ^T ) for an unknown constant T . In either case, ZIP regression models are easy to fit. The maximum likelihood estimates (MLE's) are approximately normal in large samples, and confidence intervals can be constructed by inverting likelihood ratio tests or using the approximate normality of the MLE's. Simulations suggest that the confidence intervals based on likelihood ratio tests are better, however. Finally, ZIP regression models are not only easy to interpret, but they can also lead to more refined data analyses. For example, in an experiment concerning soldering defects on printed wiring boards, two sets of conditions gave about the same mean number of defects, but the perfect state was more likely under one set of conditions and the mean number of defects in the imperfect state was smaller under the other set of conditions; that is, ZIP regression can show not only which conditions give lower mean number of defects but also why the means are lower.