The effect of ozone exposure on the ability of human surfactant protein a variants to stimulate cytokine production.
G Wang, TM Umstead, DS Phelps… - Environmental …, 2002 - ehp.niehs.nih.gov
Ozone exposure can cause inflammation and impaired lung function. Human surfactant
protein A (SP-A) may play a role in inflammation by modulating cytokine production by
macrophages. SP-A is encoded by two genes, SP-A1 and SP-A2, and several allelic
variants have been characterized for each gene. These allelic variants differ among
themselves in amino acids that may exhibit differential sensitivity to ozone-induced oxidation
and this may produce functional differences. We studied the effects of SP-A variants before …
protein A (SP-A) may play a role in inflammation by modulating cytokine production by
macrophages. SP-A is encoded by two genes, SP-A1 and SP-A2, and several allelic
variants have been characterized for each gene. These allelic variants differ among
themselves in amino acids that may exhibit differential sensitivity to ozone-induced oxidation
and this may produce functional differences. We studied the effects of SP-A variants before …