Endoglin selectively modulates transient receptor potential channel expression in left and right heart failure
KJ Morine, V Paruchuri, X Qiao, M Aronovitz… - Cardiovascular …, 2016 - Elsevier
Introduction Transient receptor potential (TRP) channels are broadly expressed cation
channels that mediate diverse physiological stimuli and include canonical (TRPC),
melastatin (TRPM), and vanilloid (TRPV) subtypes. Recent studies have implicated a role for
TRPC6 channels as an important component of signaling via the cytokine, transforming
growth factor beta 1 (TGFβ1) in right (RV) or left ventricular (LV) failure. Endoglin (Eng) is a
transmembrane glycoprotein that promotes TRPC6 expression and TGFβ1 activity. No …
channels that mediate diverse physiological stimuli and include canonical (TRPC),
melastatin (TRPM), and vanilloid (TRPV) subtypes. Recent studies have implicated a role for
TRPC6 channels as an important component of signaling via the cytokine, transforming
growth factor beta 1 (TGFβ1) in right (RV) or left ventricular (LV) failure. Endoglin (Eng) is a
transmembrane glycoprotein that promotes TRPC6 expression and TGFβ1 activity. No …