Notch receptors are involved in a variety of cell-fate decisions that affect the development
and function of many organs, including hematopoiesis and the immune system. There are
four mammalian Notch receptors that have only partially overlapping functions despite
sharing similar structures and ligands. The ligands for Notch are transmembrane proteins
expressed on adjacent cells, including Jagged and Delta, and it is quite possible that
signaling is bidirectional. A large Notch precursor protein is proteolytically cleaved to form …