Adrenomedullin ameliorates the development of atherosclerosis in apoE−/− mice
CS Pan, J Zhang, F Yu, X Teng, CQ Cao, W Wu… - Peptides, 2010 - Elsevier
Adrenomedullin (ADM) is a multifunctional peptide regulating cardiovascular homeostasis.
We studied the role of ADM in the pathogenesis of atherosclerosis by investigating changes
in ADM and its receptors–calcitonin receptor-like receptor (CRLR) and receptor activity-
modifying proteins (RAMPs)–in aorta of apoE−/− mice and the effect of exogenous ADM
administration. ApoE−/− mice were fed an atherogenic diet for 4 weeks, and apoE−/−+ ADM
mice were additionally given subcutaneous injections of ADM, 300ng/kg/h, for 4 weeks …
We studied the role of ADM in the pathogenesis of atherosclerosis by investigating changes
in ADM and its receptors–calcitonin receptor-like receptor (CRLR) and receptor activity-
modifying proteins (RAMPs)–in aorta of apoE−/− mice and the effect of exogenous ADM
administration. ApoE−/− mice were fed an atherogenic diet for 4 weeks, and apoE−/−+ ADM
mice were additionally given subcutaneous injections of ADM, 300ng/kg/h, for 4 weeks …