Adrenomedullin is increased by pulsatile shear stress on the vascular endothelium via periodic acceleration (pGz)
A Martínez, J Arias, JA Bassuk, H Wu, P Kurlansky… - Peptides, 2008 - Elsevier
Periodic acceleration (pGz) is produced by a platform which moves the supine body
repetitively in a headward to footward direction. The imparted motion produces pulsatile
shear stress on the vascular endothelium. Pulsatile shear stress on the vascular
endothelium has been shown to elicit production of a host of cardioprotective, cytoprotective
mediators. The purpose of this study was to ascertain if pGz also enhances production of
adrenomedullin (AM) in normal healthy swine. Twelve pigs (weight range 20–30kg) were …
repetitively in a headward to footward direction. The imparted motion produces pulsatile
shear stress on the vascular endothelium. Pulsatile shear stress on the vascular
endothelium has been shown to elicit production of a host of cardioprotective, cytoprotective
mediators. The purpose of this study was to ascertain if pGz also enhances production of
adrenomedullin (AM) in normal healthy swine. Twelve pigs (weight range 20–30kg) were …