[HTML][HTML] Elevated cyclic AMP inhibits NF-κB-mediated transcription in human monocytic cells and endothelial cells
V Ollivier, GCN Parry, RR Cobb, D de Prost… - Journal of Biological …, 1996 - ASBMB
The NF-κB/Rel family of transcription factors regulates the inducible expression of many
genes in activated human monocytes and endothelial cells. In this study, we examined the
molecular mechanism by which agents that elevate intracellular cAMP inhibit the expression
of the tumor necrosis factor α (TNFα), tissue factor, endothelial leukocyte adhesion molecule-
1, and vascular cell adhesion molecule-1 genes. Both forskolin and dibutyryl cAMP, which
elevate intracellular cAMP by independent mechanisms, inhibited TNFα and tissue factor …
genes in activated human monocytes and endothelial cells. In this study, we examined the
molecular mechanism by which agents that elevate intracellular cAMP inhibit the expression
of the tumor necrosis factor α (TNFα), tissue factor, endothelial leukocyte adhesion molecule-
1, and vascular cell adhesion molecule-1 genes. Both forskolin and dibutyryl cAMP, which
elevate intracellular cAMP by independent mechanisms, inhibited TNFα and tissue factor …