[HTML][HTML] Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer
K Mahajan, D Coppola, B Rawal, YA Chen… - Journal of Biological …, 2012 - ASBMB
Androgen deprivation therapy has been the standard of care in prostate cancer due to its
effectiveness in initial stages. However, the disease recurs, and this recurrent cancer is
referred to as castration-resistant prostate cancer (CRPC). Radiotherapy is the treatment of
choice; however, in addition to androgen independence, CRPC is often resistant to
radiotherapy, making radioresistant CRPC an incurable disease. The molecular
mechanisms by which CRPC cells acquire radioresistance are unclear. Androgen receptor …
effectiveness in initial stages. However, the disease recurs, and this recurrent cancer is
referred to as castration-resistant prostate cancer (CRPC). Radiotherapy is the treatment of
choice; however, in addition to androgen independence, CRPC is often resistant to
radiotherapy, making radioresistant CRPC an incurable disease. The molecular
mechanisms by which CRPC cells acquire radioresistance are unclear. Androgen receptor …