Molecular biology of sodium channels and their role in cardiac arrhythmias
AO Grant - The American journal of medicine, 2001 - Elsevier
The sodium channel is an integral membrane protein that plays a central role in conduction
of the cardiac impulse in working cardiac myocytes and cells of the His-Purkinje system. The
channel has two fundamental properties, ion conduction and gating. Specific domains of the
channel protein control each of these functions. Ion conduction describes the mechanisms of
the selective movement of sodium ion across the pore in the cell membrane. The selectivity
of the channel for sodium ions is at least 10 times greater than that for other monovalent …
of the cardiac impulse in working cardiac myocytes and cells of the His-Purkinje system. The
channel has two fundamental properties, ion conduction and gating. Specific domains of the
channel protein control each of these functions. Ion conduction describes the mechanisms of
the selective movement of sodium ion across the pore in the cell membrane. The selectivity
of the channel for sodium ions is at least 10 times greater than that for other monovalent …