RBM25/LUC7L3 function in cardiac sodium channel splicing regulation of human heart failure
G Gao, SC Dudley Jr - Trends in cardiovascular medicine, 2013 - Elsevier
Alternative splicing is a posttranscriptional mechanism that can substantially change the
pattern of gene expression. Up to 95% of human genes have multiexon alternative spliced
forms, suggesting that alternative splicing is one of the most significant components of the
functional complexity of the human genome. Nevertheless, alternative splicing regulation
has received comparatively little attention in the study of cardiac diseases. When
investigating SCN5A splicing abnormalities in heart failure (HF), we found that 47 of 181 …
pattern of gene expression. Up to 95% of human genes have multiexon alternative spliced
forms, suggesting that alternative splicing is one of the most significant components of the
functional complexity of the human genome. Nevertheless, alternative splicing regulation
has received comparatively little attention in the study of cardiac diseases. When
investigating SCN5A splicing abnormalities in heart failure (HF), we found that 47 of 181 …