Ablative hypofractionated radiation therapy enhances non-small cell lung cancer cell killing via preferential stimulation of necroptosis in vitro and in vivo
HH Wang, ZQ Wu, D Qian, NG Zaorsky, MH Qiu… - International Journal of …, 2018 - Elsevier
Purpose To investigate how necroptosis (ie, programmed necrosis) is involved in killing of
non-small cell lung cancer (NSCLC) after ablative hypofractionated radiation therapy
(HFRT). Methods and Materials Deoxyribonucleic acid damage, DNA repair, and the death
form of NSCLC cells were assessed after radiation therapy. The overexpression and
silencing of receptor-interacting protein kinases 3 (RIP3, a key protein involved activation of
necroptosis)-stable NSCLC cell lines were successfully constructed. The form of cell death …
non-small cell lung cancer (NSCLC) after ablative hypofractionated radiation therapy
(HFRT). Methods and Materials Deoxyribonucleic acid damage, DNA repair, and the death
form of NSCLC cells were assessed after radiation therapy. The overexpression and
silencing of receptor-interacting protein kinases 3 (RIP3, a key protein involved activation of
necroptosis)-stable NSCLC cell lines were successfully constructed. The form of cell death …