Rac‐GTP ases and Rac‐GEF s in neutrophil adhesion, migration and recruitment
C Pantarelli, HCE Welch - European Journal of Clinical …, 2018 - Wiley Online Library
C Pantarelli, HCE Welch
European Journal of Clinical Investigation, 2018•Wiley Online LibraryRac‐GTP ases and their Rac‐GEF activators play important roles in the recruitment and host
defence functions of neutrophils. These proteins control the activation of adhesion
molecules and the cytoskeletal dynamics that enable the adhesion, migration and tissue
recruitment of neutrophils. They also regulate the effector functions that allow neutrophils to
kill bacterial and fungal pathogens, and to clear debris. This review focuses on the roles of
Rac‐GTP ases and Rac‐GEF s in neutrophil adhesion, migration and recruitment.
defence functions of neutrophils. These proteins control the activation of adhesion
molecules and the cytoskeletal dynamics that enable the adhesion, migration and tissue
recruitment of neutrophils. They also regulate the effector functions that allow neutrophils to
kill bacterial and fungal pathogens, and to clear debris. This review focuses on the roles of
Rac‐GTP ases and Rac‐GEF s in neutrophil adhesion, migration and recruitment.
Abstract
Rac‐GTPases and their Rac‐GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the activation of adhesion molecules and the cytoskeletal dynamics that enable the adhesion, migration and tissue recruitment of neutrophils. They also regulate the effector functions that allow neutrophils to kill bacterial and fungal pathogens, and to clear debris. This review focuses on the roles of Rac‐GTPases and Rac‐GEFs in neutrophil adhesion, migration and recruitment.
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