Mitochondria as sensors and regulators of calcium signalling
Nature reviews Molecular cell biology, 2012•nature.com
During the past two decades calcium (Ca2+) accumulation in energized mitochondria has
emerged as a biological process of utmost physiological relevance. Mitochondrial Ca2+
uptake was shown to control intracellular Ca2+ signalling, cell metabolism, cell survival and
other cell-type specific functions by buffering cytosolic Ca2+ levels and regulating
mitochondrial effectors. Recently, the identity of mitochondrial Ca2+ transporters has been
revealed, opening new perspectives for investigation and molecular intervention.
emerged as a biological process of utmost physiological relevance. Mitochondrial Ca2+
uptake was shown to control intracellular Ca2+ signalling, cell metabolism, cell survival and
other cell-type specific functions by buffering cytosolic Ca2+ levels and regulating
mitochondrial effectors. Recently, the identity of mitochondrial Ca2+ transporters has been
revealed, opening new perspectives for investigation and molecular intervention.
Abstract
During the past two decades calcium (Ca2+) accumulation in energized mitochondria has emerged as a biological process of utmost physiological relevance. Mitochondrial Ca2+ uptake was shown to control intracellular Ca2+ signalling, cell metabolism, cell survival and other cell-type specific functions by buffering cytosolic Ca2+ levels and regulating mitochondrial effectors. Recently, the identity of mitochondrial Ca2+ transporters has been revealed, opening new perspectives for investigation and molecular intervention.
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