Clinical implications of discordance between low-density lipoprotein cholesterol and particle number
JD Otvos, S Mora, I Shalaurova, P Greenland… - Journal of clinical …, 2011 - Elsevier
BACKGROUND: The amount of cholesterol per low-density lipoprotein (LDL) particle is
variable and related in part to particle size, with smaller particles carrying less cholesterol.
This variability causes concentrations of LDL cholesterol (LDL-C) and LDL particles (LDL-P)
to be discordant in many individuals. METHODS: LDL-P measured by nuclear magnetic
resonance spectroscopy, calculated LDL-C, and carotid intima-media thickness (IMT) were
assessed at baseline in the Multi-Ethnic Study of Atherosclerosis, a community-based cohort …
variable and related in part to particle size, with smaller particles carrying less cholesterol.
This variability causes concentrations of LDL cholesterol (LDL-C) and LDL particles (LDL-P)
to be discordant in many individuals. METHODS: LDL-P measured by nuclear magnetic
resonance spectroscopy, calculated LDL-C, and carotid intima-media thickness (IMT) were
assessed at baseline in the Multi-Ethnic Study of Atherosclerosis, a community-based cohort …