Evidence for active Wnt signaling during postresection intestinal adaptation
NP Bernal, W Stehr, Y Zhang, S Profitt, CR Erwin… - Journal of pediatric …, 2005 - Elsevier
BACKGROUND: In the intestine, Wnt proteins are powerful regulators of cell proliferation,
differentiation, and adhesion. Mutations of the adenomatous polyposis coli (APC) gene
elevate nuclear β-catenin and provoke intestinal tumor formation. We sought to determine
whether Wnt signaling is involved in adaptive response to massive small bowel resection
(SBR). METHODS: Male Min mice with a mutation of the APC gene and wild-type controls
underwent a 50% proximal SBR or sham operation. After 3 days, villus height, crypt depth …
differentiation, and adhesion. Mutations of the adenomatous polyposis coli (APC) gene
elevate nuclear β-catenin and provoke intestinal tumor formation. We sought to determine
whether Wnt signaling is involved in adaptive response to massive small bowel resection
(SBR). METHODS: Male Min mice with a mutation of the APC gene and wild-type controls
underwent a 50% proximal SBR or sham operation. After 3 days, villus height, crypt depth …