Mitogenic influence of human R-spondin1 on the intestinal epithelium
KA Kim, M Kakitani, J Zhao, T Oshima, T Tang… - Science, 2005 - science.org
KA Kim, M Kakitani, J Zhao, T Oshima, T Tang, M Binnerts, Y Liu, B Boyle, E Park, P Emtage…
Science, 2005•science.orgSeveral described growth factors influence the proliferation and regeneration of the
intestinal epithelium. Using a transgenic mouse model, we identified a human gene, R-
spondin1, with potent and specific proliferative effects on intestinal crypt cells. Human R-
spondin1 (hRSpo1) is a thrombospondin domain-containing protein expressed in
enteroendocrine cells as well as in epithelial cells in various tissues. Upon injection into
mice, the protein induced rapid onset of crypt cell proliferation involving β-catenin …
intestinal epithelium. Using a transgenic mouse model, we identified a human gene, R-
spondin1, with potent and specific proliferative effects on intestinal crypt cells. Human R-
spondin1 (hRSpo1) is a thrombospondin domain-containing protein expressed in
enteroendocrine cells as well as in epithelial cells in various tissues. Upon injection into
mice, the protein induced rapid onset of crypt cell proliferation involving β-catenin …
Several described growth factors influence the proliferation and regeneration of the intestinal epithelium. Using a transgenic mouse model, we identified a human gene, R-spondin1, with potent and specific proliferative effects on intestinal crypt cells. Human R-spondin1 (hRSpo1) is a thrombospondin domain-containing protein expressed in enteroendocrine cells as well as in epithelial cells in various tissues. Upon injection into mice, the protein induced rapid onset of crypt cell proliferation involving β-catenin stabilization, possibly by a process that is distinct from the canonical Wnt-mediated signaling pathway. The protein also displayed efficacy in a model of chemotherapy-induced intestinal mucositis and may have therapeutic application in gastrointestinal diseases.
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