[HTML][HTML] Deletion of Tis7 protects mice from high-fat diet-induced weight gain and blunts the intestinal adaptive response postresection
C Yu, S Jiang, J Lu, CC Coughlin, Y Wang… - The Journal of …, 2010 - Elsevier
After loss of intestinal surface area, the remaining bowel undergoes a morphometric and
functional adaptive response. Enterocytic expression of the transcriptional coregulator
tetradecanoyl phorbol acetate induced sequence 7 (Tis7) is markedly increased in a murine
model of intestinal adaptation. Mice overexpressing Tis7 in intestine have greater
triglyceride absorption and weight gain when fed a high-fat diet (42% energy) than their wild-
type (WT) littermates fed the same diet. These and other data suggest that Tis7 has a unique …
functional adaptive response. Enterocytic expression of the transcriptional coregulator
tetradecanoyl phorbol acetate induced sequence 7 (Tis7) is markedly increased in a murine
model of intestinal adaptation. Mice overexpressing Tis7 in intestine have greater
triglyceride absorption and weight gain when fed a high-fat diet (42% energy) than their wild-
type (WT) littermates fed the same diet. These and other data suggest that Tis7 has a unique …