[HTML][HTML] Human immunoglobulin heavy gamma chain polymorphisms: molecular confirmation of proteomic assessment
M Dambrun, C Dechavanne, A Emmanuel… - Molecular & Cellular …, 2017 - ASBMB
Immunoglobulin G (IgG) proteins are known for the huge diversity of the variable domains of
their heavy and light chains, aimed at protecting each individual against foreign antigens.
The IgG also harbor specific polymorphism concentrated in the CH2 and CH3-CHS constant
regions located on the Fc fragment of their heavy chains. But this individual particularity
relies only on a few amino acids among which some could make accurate sequence
determination a challenge for mass spectrometry-based techniques. The purpose of the …
their heavy and light chains, aimed at protecting each individual against foreign antigens.
The IgG also harbor specific polymorphism concentrated in the CH2 and CH3-CHS constant
regions located on the Fc fragment of their heavy chains. But this individual particularity
relies only on a few amino acids among which some could make accurate sequence
determination a challenge for mass spectrometry-based techniques. The purpose of the …