A NOX4/TRPC6 pathway in podocyte calcium regulation and renal damage in diabetic kidney disease
DV Ilatovskaya, G Blass, O Palygin… - Journal of the …, 2018 - journals.lww.com
Background Loss of glomerular podocytes is an indicator of diabetic kidney disease (DKD).
The damage to these cells has been attributed in part to elevated intrarenal oxidative stress.
The primary source of the renal reactive oxygen species, particularly H 2 O 2, is NADPH
oxidase 4 (NOX4). We hypothesized that NOX4-derived H 2 O 2 contributes to podocyte
damage in DKD via elevation of podocyte calcium. Methods We used Dahl salt-sensitive
(SS) rats with a null mutation for the Nox4 gene (SS Nox4−/−) and mice with knockout of the …
The damage to these cells has been attributed in part to elevated intrarenal oxidative stress.
The primary source of the renal reactive oxygen species, particularly H 2 O 2, is NADPH
oxidase 4 (NOX4). We hypothesized that NOX4-derived H 2 O 2 contributes to podocyte
damage in DKD via elevation of podocyte calcium. Methods We used Dahl salt-sensitive
(SS) rats with a null mutation for the Nox4 gene (SS Nox4−/−) and mice with knockout of the …