[HTML][HTML] Deficiency of Capn4 gene inhibits nuclear factor-κB (NF-κB) protein signaling/inflammation and reduces remodeling after myocardial infarction
J Ma, M Wei, Q Wang, J Li, H Wang, W Liu… - Journal of Biological …, 2012 - ASBMB
Calpain has been implicated in acute myocardial injury after myocardial infarction (MI).
However, the causal relationship between calpain and post-MI myocardial remodeling has
not been fully understood. This study examined whether deletion of Capn4, essential for
calpain-1 and calpain-2 activities, reduces myocardial remodeling and dysfunction following
MI, and if yes, whether these effects of Capn4 deletion are associated with NF-κB signaling
and inflammatory responses in the MI heart. A novel mouse model with cardiomyocyte …
However, the causal relationship between calpain and post-MI myocardial remodeling has
not been fully understood. This study examined whether deletion of Capn4, essential for
calpain-1 and calpain-2 activities, reduces myocardial remodeling and dysfunction following
MI, and if yes, whether these effects of Capn4 deletion are associated with NF-κB signaling
and inflammatory responses in the MI heart. A novel mouse model with cardiomyocyte …
