[HTML][HTML] Low Molecular Weight Hyaluronan Activates Cytosolic Phospholipase A2α and Eicosanoid Production in Monocytes and Macrophages*♦
M Sokolowska, LY Chen, M Eberlein… - Journal of Biological …, 2014 - ASBMB
Hyaluronan (HA) is the major glycosaminoglycan in the extracellular matrix. During
inflammation, there is an increased breakdown of HA, resulting in the accumulation of low
molecular weight (LMW) HA and activation of monocytes and macrophages. Eicosanoids,
derived from the cytosolic phospholipase A 2 group IVA (cPLA 2 α) activation, are potent
lipid mediators also attributed to acute and chronic inflammation. The aim of this study was
to determine the effect of LMW HA on cPLA 2 α activation, arachidonic acid (AA) release …
inflammation, there is an increased breakdown of HA, resulting in the accumulation of low
molecular weight (LMW) HA and activation of monocytes and macrophages. Eicosanoids,
derived from the cytosolic phospholipase A 2 group IVA (cPLA 2 α) activation, are potent
lipid mediators also attributed to acute and chronic inflammation. The aim of this study was
to determine the effect of LMW HA on cPLA 2 α activation, arachidonic acid (AA) release …