[HTML][HTML] Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα)
HC Dan, A Ebbs, M Pasparakis, T Van Dyke… - Journal of Biological …, 2014 - ASBMB
The serine/threonine protein kinase Akt promotes cell survival, growth, and proliferation
through phosphorylation of different downstream substrates. A key effector of Akt is the
mammalian target of rapamycin (mTOR). Akt is known to stimulate mTORC1 activity through
phosphorylation of tuberous sclerosis complex 2 (TSC2) and PRAS40, both negative
regulators of mTOR activity. We previously reported that IκB kinase α (IKKα), a component of
the kinase complex that leads to NF-κB activation, plays an important role in promoting …
through phosphorylation of different downstream substrates. A key effector of Akt is the
mammalian target of rapamycin (mTOR). Akt is known to stimulate mTORC1 activity through
phosphorylation of tuberous sclerosis complex 2 (TSC2) and PRAS40, both negative
regulators of mTOR activity. We previously reported that IκB kinase α (IKKα), a component of
the kinase complex that leads to NF-κB activation, plays an important role in promoting …