Therapeutic implications of autoantibodies in rheumatoid arthritis

D Aletaha, S Blüml - RMD open, 2016 - rmdopen.bmj.com
RMD open, 2016rmdopen.bmj.com
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterised by the presence
of autoantibodies. Their value for diagnostic/prognostic purposes has been well established.
In contrast, their role in established disease and their associations with disease activity is
less clear. Moreover, as evidence is accumulating that these autoantibodies are causally
involved in certain key aspects of the disease, such as the initiation and perpetuation of joint
inflammation or join destruction, autoantibodies in RA can no longer be regarded as mere …
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterised by the presence of autoantibodies. Their value for diagnostic/prognostic purposes has been well established. In contrast, their role in established disease and their associations with disease activity is less clear. Moreover, as evidence is accumulating that these autoantibodies are causally involved in certain key aspects of the disease, such as the initiation and perpetuation of joint inflammation or join destruction, autoantibodies in RA can no longer be regarded as mere epiphenomena, but are integral elements of the pathophysiology of RA.
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