The regulation of IL-10 expression

L Gabryšová, A Howes, M Saraiva… - Interleukin-10 in Health …, 2014 - Springer
L Gabryšová, A Howes, M Saraiva, A O'Garra
Interleukin-10 in Health and Disease, 2014Springer
Abstract Interleukin (IL)-10 is an important immunoregulatory cytokine and an understanding
of how IL-10 expression is controlled is critical in the design of immune intervention
strategies. IL-10 is produced by almost all cell types within the innate (including
macrophages, monocytes, dendritic cells (DCs), mast cells, neutrophils, eosinophils and
natural killer cells) and adaptive (including CD4+ T cells, CD8+ T cells and B cells) immune
systems. The mechanisms of IL-10 regulation operate at several stages including chromatin …
Abstract
Interleukin (IL)-10 is an important immunoregulatory cytokine and an understanding of how IL-10 expression is controlled is critical in the design of immune intervention strategies. IL-10 is produced by almost all cell types within the innate (including macrophages, monocytes, dendritic cells (DCs), mast cells, neutrophils, eosinophils and natural killer cells) and adaptive (including CD4+ T cells, CD8+ T cells and B cells) immune systems. The mechanisms of IL-10 regulation operate at several stages including chromatin remodelling at the Il10 locus, transcriptional regulation of Il10 expression and post-transcriptional regulation of Il10 mRNA. In addition, whereas some aspects of Il10 gene regulation are conserved between different immune cell types, several are cell type- or stimulus-specific. Here, we outline the complexity of IL-10 production by discussing what is known about its regulation in macrophages, monocytes, DCs and CD4+ T helper cells.
Springer