[HTML][HTML] Mesenchymal stromal cells: role in the BM niche and in the support of hematopoietic stem cell transplantation

S Crippa, ME Bernardo - Hemasphere, 2018 - journals.lww.com
Mesenchymal stromal cells (MSCs) are key elements in the bone marrow (BM) niche where
they interact with hematopoietic stem progenitor cells (HSPCs) by offering physical support
and secreting soluble factors, which control HSPC maintenance and fate. Although
necessary for their maintenance, MSCs are a rare population in the BM, they are plastic
adherent and can be ex vivo expanded to reach numbers adequate for clinical use. In light
of HSPC supportive properties, MSCs have been employed in phase I/II clinical trials of …