Heterogeneity of the bone marrow niche
WC Vionnie, DT Scadden - Current opinion in hematology, 2016 - journals.lww.com
WC Vionnie, DT Scadden
Current opinion in hematology, 2016•journals.lww.comThe emerging concept is that the bone marrow environment is composed of multiple
microniches, each consisting of unique pairing of distinct supportive stromal cells with
distinct hematopoietic subtypes to regulate a particular branch of hematopoietic cell process.
The bone marrow can be viewed as a carrier with subcompartments tailored to support
different hematopoietic activities.
microniches, each consisting of unique pairing of distinct supportive stromal cells with
distinct hematopoietic subtypes to regulate a particular branch of hematopoietic cell process.
The bone marrow can be viewed as a carrier with subcompartments tailored to support
different hematopoietic activities.
Summary
The emerging concept is that the bone marrow environment is composed of multiple microniches, each consisting of unique pairing of distinct supportive stromal cells with distinct hematopoietic subtypes to regulate a particular branch of hematopoietic cell process. The bone marrow can be viewed as a carrier with subcompartments tailored to support different hematopoietic activities.
Lippincott Williams & Wilkins