Involvement of the choroid plexus in multiple sclerosis autoimmune inflammation: a neuropathological study
M Vercellino, B Votta, C Condello, C Piacentino… - Journal of …, 2008 - Elsevier
An immunological function has been proposed for the choroid plexus (CP). In multiple
sclerosis (MS) brains, CPs show (immunohistochemistry to HLA-DR, CD3, CD20, CD68,
VCAM-1, CD138) T lymphocytes in vessels and stroma, VCAM-1 expression on endothelia,
intense HLA-DR immunostaining on cells in CP stroma, among CP epithelium and on
epiplexus cells. CPs in control or amyotrophic lateral sclerosis brains do not show such
inflammatory changes. Intense CP inflammation is observed in viral encephalitis. Changes …
sclerosis (MS) brains, CPs show (immunohistochemistry to HLA-DR, CD3, CD20, CD68,
VCAM-1, CD138) T lymphocytes in vessels and stroma, VCAM-1 expression on endothelia,
intense HLA-DR immunostaining on cells in CP stroma, among CP epithelium and on
epiplexus cells. CPs in control or amyotrophic lateral sclerosis brains do not show such
inflammatory changes. Intense CP inflammation is observed in viral encephalitis. Changes …