PHLAT: inference of high-resolution HLA types from RNA and whole exome sequencing
Y Bai, D Wang, W Fury - HLA Typing: Methods and Protocols, 2018 - Springer
Y Bai, D Wang, W Fury
HLA Typing: Methods and Protocols, 2018•SpringerInferring HLA types from genome-wide sequencing data has gained growing attention with
the development of new cost-efficient sequencing technologies and the increasing need to
integrate HLA types with transcriptomic or other genomic information for insights into
immune-mediated diseases, vaccination, and cancer immunotherapy. PHLAT is a
computational tool designed for high-resolution (4-digit) typing of the major class I and class
II HLA genes using RNAseq or exome sequencing data as input. We illustrate here how …
the development of new cost-efficient sequencing technologies and the increasing need to
integrate HLA types with transcriptomic or other genomic information for insights into
immune-mediated diseases, vaccination, and cancer immunotherapy. PHLAT is a
computational tool designed for high-resolution (4-digit) typing of the major class I and class
II HLA genes using RNAseq or exome sequencing data as input. We illustrate here how …
Abstract
Inferring HLA types from genome-wide sequencing data has gained growing attention with the development of new cost-efficient sequencing technologies and the increasing need to integrate HLA types with transcriptomic or other genomic information for insights into immune-mediated diseases, vaccination, and cancer immunotherapy. PHLAT is a computational tool designed for high-resolution (4-digit) typing of the major class I and class II HLA genes using RNAseq or exome sequencing data as input. We illustrate here how PHLAT can be installed, configured, and executed. This document also provides guidance for how to read and interpret the output results. Finally, the best practices of using PHLAT are also discussed.
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