Intracellular accumulation of subviral HBsAg particles and diminished Nrf2 activation in HBV genotype G expressing cells lead to an increased ROI level

KH Peiffer, S Akhras, K Himmelsbach, M Hassemer… - Journal of …, 2015 - Elsevier
Background & Aims Hepatitis B virus genotype G (HBV/G) is characterized by a lack of
HBeAg secretion and very low HBsAg secretion. This study aimed at (1) comparing HBV
genotype G and A2 with respect to morphogenesis and release of HBV-derived particles,(2)
characterizing factors contributing to HBV/G-associated pathogenesis. Methods HBV/G-and
HBV/A-expressing hepatoma cells and infected HepaRG cells were analyzed by confocal
laser scanning microscopy, Western blot, real-time PCR, density gradient centrifugation, and …