Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia
OA Dina, T Hucho, J Yeh, M Malik-Hall, DB Reichling… - Pain, 2005 - Elsevier
We recently reported that hyperalgesia induced by the inflammatory mediator prostaglandin
E2 (PGE2) requires intact α1, α3 and β1 integrin subunit function, whereas epinephrine-
induced hyperalgesia depends on α5 and β1. PGE2-induced hyperalgesia is mediated by
protein kinase A (PKA), while epinephrine-induced hyperalgesia is mediated by a
combination of PKA, protein kinase Cε (PKCε) and mitogen-activated protein
kinase/extracellular signal-regulated kinase (MAPK/ERK). We hypothesized that …
E2 (PGE2) requires intact α1, α3 and β1 integrin subunit function, whereas epinephrine-
induced hyperalgesia depends on α5 and β1. PGE2-induced hyperalgesia is mediated by
protein kinase A (PKA), while epinephrine-induced hyperalgesia is mediated by a
combination of PKA, protein kinase Cε (PKCε) and mitogen-activated protein
kinase/extracellular signal-regulated kinase (MAPK/ERK). We hypothesized that …