Safety and efficacy of pazopanib therapy prior to planned nephrectomy in metastatic clear cell renal cancer
T Powles, N Sarwar, A Stockdale, SJ Sarker… - JAMA …, 2016 - jamanetwork.com
Importance The role of cytoreductive nephrectomy in patients with metastatic renal cancer in
the era of targeted therapy is uncertain. Objective To establish the safety and efficacy of
upfront pazopanib therapy prior to cytoreductive nephrectomy in previously untreated
patients with metastatic clear cell renal cancer. Design, Setting, and Participants Single-arm
phase 2 study of 104 previously untreated patients with metastatic clear cell renal cancer
recruited between June 2008 and October 2012 at cancer treatment centers with access to …
the era of targeted therapy is uncertain. Objective To establish the safety and efficacy of
upfront pazopanib therapy prior to cytoreductive nephrectomy in previously untreated
patients with metastatic clear cell renal cancer. Design, Setting, and Participants Single-arm
phase 2 study of 104 previously untreated patients with metastatic clear cell renal cancer
recruited between June 2008 and October 2012 at cancer treatment centers with access to …