Systemic and local cytokine profiles in endotoxin-induced preterm parturition in mice
PL Fidel Jr, R Romero, N Wolf, J Cutright… - American journal of …, 1994 - Elsevier
OBJECTIVE: Our purpose was to determine whether endotoxin-induced preterm parturition
is preceded by a change in the maternal serum and amniotic fluid concentrations of tumor
necrosis factor-α, interleukin-6, and interleukin-1α. STUDY DESIGN: C3H/HeN pregnant
mice at 15 days of gestation (70% gestation) were randomized to receive an intraperitoneal
injection of phosphate-buffered saline solution or lipopolysaccharide (50 μg/mouse). Blood
(n= 93) and amniotic fluid (n= 58) were collected at 1, 4, and 10 hours after …
is preceded by a change in the maternal serum and amniotic fluid concentrations of tumor
necrosis factor-α, interleukin-6, and interleukin-1α. STUDY DESIGN: C3H/HeN pregnant
mice at 15 days of gestation (70% gestation) were randomized to receive an intraperitoneal
injection of phosphate-buffered saline solution or lipopolysaccharide (50 μg/mouse). Blood
(n= 93) and amniotic fluid (n= 58) were collected at 1, 4, and 10 hours after …