[HTML][HTML] Low interleukin-2 concentration favors generation of early memory T cells over effector phenotypes during chimeric antigen receptor T-cell expansion
T Kaartinen, A Luostarinen, P Maliniemi, J Keto… - Cytotherapy, 2017 - Elsevier
Background Adoptive T-cell therapy offers new options for cancer treatment. Clinical results
suggest that T-cell persistence, depending on T-cell memory, improves efficacy. The use of
interleukin (IL)-2 for in vitro T-cell expansion is not straightforward because it drives effector
T-cell differentiation but does not promote the formation of T-cell memory. We have
developed a cost-effective expansion protocol for chimeric antigen receptor (CAR) T cells
with an early memory phenotype. Methods Lymphocytes were transduced with third …
suggest that T-cell persistence, depending on T-cell memory, improves efficacy. The use of
interleukin (IL)-2 for in vitro T-cell expansion is not straightforward because it drives effector
T-cell differentiation but does not promote the formation of T-cell memory. We have
developed a cost-effective expansion protocol for chimeric antigen receptor (CAR) T cells
with an early memory phenotype. Methods Lymphocytes were transduced with third …