[HTML][HTML] A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics
A Raskin, S Lange, K Banares, RC Lyon… - Journal of Biological …, 2012 - ASBMB
Understanding mechanisms underlying titin regulation in cardiac muscle function is of
critical importance given recent compelling evidence that highlight titin mutations as major
determinants of human cardiomyopathy. We previously identified a cardiac biomechanical
stress-regulated complex at the cardiac-specific N2B region of titin that includes four-and-a-
half LIM domain protein-1 (Fhl1) and components of the mitogen-activated protein signaling
cascade, which impacted muscle compliance in Fhl1 knock-out cardiac muscle. However …
critical importance given recent compelling evidence that highlight titin mutations as major
determinants of human cardiomyopathy. We previously identified a cardiac biomechanical
stress-regulated complex at the cardiac-specific N2B region of titin that includes four-and-a-
half LIM domain protein-1 (Fhl1) and components of the mitogen-activated protein signaling
cascade, which impacted muscle compliance in Fhl1 knock-out cardiac muscle. However …
