Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase
Y Nakabeppu, S Oka, Z Sheng, D Tsuchimoto… - … /Genetic Toxicology and …, 2010 - Elsevier
Accumulation of oxidized bases such as 8-oxoguanine in either nuclear or mitochondrial
DNA triggers various cellular dysfunctions including mutagenesis, and programmed cell
death or senescence. Recent studies have revealed that oxidized nucleoside triphosphates
such as 8-oxo-dGTP in the nucleotide pool are the main source of oxidized bases
accumulating in the DNA of cells under oxidative stress. To counteract such deleterious
effects of nucleotide pool damage, mammalian cells possess MutT homolog-1 (MTH1) with …
DNA triggers various cellular dysfunctions including mutagenesis, and programmed cell
death or senescence. Recent studies have revealed that oxidized nucleoside triphosphates
such as 8-oxo-dGTP in the nucleotide pool are the main source of oxidized bases
accumulating in the DNA of cells under oxidative stress. To counteract such deleterious
effects of nucleotide pool damage, mammalian cells possess MutT homolog-1 (MTH1) with …