ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells
K Sakumi, N Abolhassani, M Behmanesh… - … /Genetic Toxicology and …, 2010 - Elsevier
Inosine triphosphate pyrophosphatase (ITPA protein)(EC 3.6. 1.19) hydrolyzes deaminated
purine nucleoside triphosphates, such as ITP and dITP, to their corresponding purine
nucleoside monophosphate and pyrophosphate. In mammals, this enzyme is encoded by
the Itpa gene. Using the Itpa gene-disrupted mouse as a model, we have elucidated the
biological significance of the ITPA protein and its substrates, ITP and dITP. Itpa−/− mice
exhibited peri-or post-natal lethality dependent on the genetic background. The heart of the …
purine nucleoside triphosphates, such as ITP and dITP, to their corresponding purine
nucleoside monophosphate and pyrophosphate. In mammals, this enzyme is encoded by
the Itpa gene. Using the Itpa gene-disrupted mouse as a model, we have elucidated the
biological significance of the ITPA protein and its substrates, ITP and dITP. Itpa−/− mice
exhibited peri-or post-natal lethality dependent on the genetic background. The heart of the …