[HTML][HTML] Randomized, prospective evaluation comparing intensity of lymphodepletion before adoptive transfer of tumor-infiltrating lymphocytes for patients with …

SL Goff, ME Dudley, DE Citrin… - Journal of Clinical …, 2016 - ncbi.nlm.nih.gov
SL Goff, ME Dudley, DE Citrin, RP Somerville, JR Wunderlich, DN Danforth, DA Zlott…
Journal of Clinical Oncology, 2016ncbi.nlm.nih.gov
Purpose Adoptive cell transfer, the infusion of large numbers of activated autologous
lymphocytes, can mediate objective tumor regression in a majority of patients with metastatic
melanoma (52 of 93; 56%). Addition and intensification of total body irradiation (TBI) to the
preparative lymphodepleting chemotherapy regimen in sequential trials improved objective
partial and complete response (CR) rates. Here, we evaluated the importance of adding TBI
to the adoptive transfer of tumor-infiltrating lymphocytes (TIL) in a randomized fashion.
Abstract
Purpose
Adoptive cell transfer, the infusion of large numbers of activated autologous lymphocytes, can mediate objective tumor regression in a majority of patients with metastatic melanoma (52 of 93; 56%). Addition and intensification of total body irradiation (TBI) to the preparative lymphodepleting chemotherapy regimen in sequential trials improved objective partial and complete response (CR) rates. Here, we evaluated the importance of adding TBI to the adoptive transfer of tumor-infiltrating lymphocytes (TIL) in a randomized fashion.
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