Obesity is a growing epidemic and a common problem among reproductive-age men that
can both cause and exacerbate male-factor infertility by means of endocrine abnormalities,
associated comorbidities, and direct effects on the fidelity and throughput of
spermatogenesis. Robust epidemiologic, clinical, genetic, epigenetic, and nonhuman
animal data support these findings. Recent works in the burgeoning field of epigenetics has
demonstrated that paternal obesity can affect offspring metabolic and reproductive …