[HTML][HTML] Intestinal threonine utilization for protein and mucin synthesis is decreased in formula-fed preterm pigs
PJ Puiman, M Jensen, B Stoll, IB Renes… - The Journal of …, 2011 - Elsevier
Threonine is an essential amino acid necessary for synthesis of intestinal (glyco) proteins
such as mucin MUC2 to maintain adequate gut barrier function. In premature infants,
reduced barrier function may contribute to the development of necrotizing enterocolitis
(NEC). Human milk protects against NEC compared with infant formula. Therefore, we
hypothesized that formula feeding decreases the MUC2 synthesis rate concomitant with a
decrease in intestinal first-pass threonine utilization, predisposing the preterm neonate to …
such as mucin MUC2 to maintain adequate gut barrier function. In premature infants,
reduced barrier function may contribute to the development of necrotizing enterocolitis
(NEC). Human milk protects against NEC compared with infant formula. Therefore, we
hypothesized that formula feeding decreases the MUC2 synthesis rate concomitant with a
decrease in intestinal first-pass threonine utilization, predisposing the preterm neonate to …