Longevity of mice can be increased by spontaneous or experimentally induced mutations
that interfere with the biosynthesis or actions of growth hormone (GH), insulin-like growth
factor 1 (IGF-1), or insulin in the adipose tissue. The effects of GH resistance and deficiency
of GH (along with thyrotropin and prolactin) on aging and lifespan are the most pronounced
and best established of these mutations. Potential mechanisms linking these endocrine
deficits with delayed aging and extended longevity include increased stress resistance …