Inhibiting microRNA-192 ameliorates renal fibrosis in diabetic nephropathy
S Putta, L Lanting, G Sun, G Lawson… - Journal of the …, 2012 - journals.lww.com
Abstract TGF-β1 upregulates microRNA-192 (miR-192) in cultured glomerular mesangial
cells and in glomeruli from diabetic mice. miR-192 not only increases collagen expression
by targeting the E-box repressors Zeb1/2 but also modulates other renal miRNAs,
suggesting that it may be a therapeutic target for diabetic nephropathy. We evaluated the
efficacy of a locked nucleic acid (LNA)–modified inhibitor of miR-192, designated LNA–anti-
miR-192, in mouse models of diabetic nephropathy. LNA–anti-miR-192 significantly reduced …
cells and in glomeruli from diabetic mice. miR-192 not only increases collagen expression
by targeting the E-box repressors Zeb1/2 but also modulates other renal miRNAs,
suggesting that it may be a therapeutic target for diabetic nephropathy. We evaluated the
efficacy of a locked nucleic acid (LNA)–modified inhibitor of miR-192, designated LNA–anti-
miR-192, in mouse models of diabetic nephropathy. LNA–anti-miR-192 significantly reduced …