[HTML][HTML] MicroRNA MiR-199a-5p regulates smooth muscle cell proliferation and morphology by targeting WNT2 signaling pathway
MicroRNA miR-199a-5p impairs tight junction formation, leading to increased urothelial
permeability in bladder pain syndrome. Now, using transcriptome analysis in urothelial TEU-
2 cells, we implicate it in the regulation of cell cycle, cytoskeleton remodeling, TGF, and WNT
signaling pathways. MiR-199a-5p is highly expressed in the smooth muscle layer of the
bladder, and we altered its levels in bladder smooth muscle cells (SMCs) to validate the
pathway analysis. Inhibition of miR-199a-5p with antimiR increased SMC proliferation …
permeability in bladder pain syndrome. Now, using transcriptome analysis in urothelial TEU-
2 cells, we implicate it in the regulation of cell cycle, cytoskeleton remodeling, TGF, and WNT
signaling pathways. MiR-199a-5p is highly expressed in the smooth muscle layer of the
bladder, and we altered its levels in bladder smooth muscle cells (SMCs) to validate the
pathway analysis. Inhibition of miR-199a-5p with antimiR increased SMC proliferation …