Retinal angiogenesis in development and disease

RF Gariano, TW Gardner - Nature, 2005 - nature.com
RF Gariano, TW Gardner
Nature, 2005nature.com
The retina has long been regarded as 'an approachable part of the brain'for investigating
neurosensory processes. Cell biologists are now capitalizing on the accessibility of the
retina to investigate important aspects of developmental angiogenesis, including how it
relates to neuronal and glial development, morphogenesis, oxygen sensing and progenitor
cells. Pathological angiogenesis also occurs in the retina and is a major feature of leading
blinding diseases, particularly diabetic retinopathy. The retina and its clinical disorders have …
Abstract
The retina has long been regarded as ‘an approachable part of the brain’ for investigating neurosensory processes. Cell biologists are now capitalizing on the accessibility of the retina to investigate important aspects of developmental angiogenesis, including how it relates to neuronal and glial development, morphogenesis, oxygen sensing and progenitor cells. Pathological angiogenesis also occurs in the retina and is a major feature of leading blinding diseases, particularly diabetic retinopathy. The retina and its clinical disorders have a pivotal role in angiogenesis research and provide model systems in which to investigate neurovascular relationships and angiogenic diseases.
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