Neurosurgical management and prognosis of patients with glioblastoma that progresses during bevacizumab treatment

AJ Clark, KR Lamborn, NA Butowski, SM Chang… - …, 2012 - journals.lww.com
BACKGROUND: The management and prognosis of glioblastoma patients after Stupp
protocol treatment and progression during bevacizumab (BV) treatment remain undefined.
OBJECTIVE: We compared the morbidity and survival of patients whose glioblastomas
progressed during BV treatment requiring craniotomy with those of patients not treated with
BV. METHODS: We retrospectively reviewed patients who underwent craniotomy for
recurrent glioblastoma from 2005 to 2009. Patients operated on for progression during BV …