Glucocorticoids are important regulators of lipid homeostasis, and chronically elevated
glucocorticoid levels induce hypertriglyceridemia, hepatic steatosis, and visceral obesity.
The occupied glucocorticoid receptor (GR) is a transcription factor. However, those genes
regulating lipid metabolism under GR control are not fully known. Angiopoietin-like 4
(ANGPTL4, fasting-induced adipose factor), a protein inhibitor of lipoprotein lipase, is
synthesized and secreted during fasting, when circulating glucocorticoid levels are …