Gene expression of GLUT3 and GLUT1 glucose transporters in human brain tumors
RJ Boado, KL Black, WM Pardridge - Molecular Brain Research, 1994 - Elsevier
GLUT3 glucose transporter gene expression is confined to neurons, while GLUT1 gene
expression is limited to endothelial cells in normal brain. Thus far, neither of the GLUT genes
has been shown to be consistently expressed in glial cells in adult brain in vivo under
normal conditions. However, GLUT gene expression may be aberrant in human brain glial
tumors. The present investigation shows that the GLUT1 and GLUT3 transcripts are
differentially expressed in a series of 20 human brain tumors. The GLUT1/actin mRNA ratio …
expression is limited to endothelial cells in normal brain. Thus far, neither of the GLUT genes
has been shown to be consistently expressed in glial cells in adult brain in vivo under
normal conditions. However, GLUT gene expression may be aberrant in human brain glial
tumors. The present investigation shows that the GLUT1 and GLUT3 transcripts are
differentially expressed in a series of 20 human brain tumors. The GLUT1/actin mRNA ratio …
