[HTML][HTML] Differential effects of mitochondrial heat shock protein 60 and related molecular chaperones to prevent intracellular β-amyloid-induced inhibition of complex IV …
Defects in mitochondrial oxidative metabolism, in particular decreased activity of cytochrome
c oxidase, have been reported in Alzheimer disease tissue and in cultured cells that
overexpress amyloid precursor protein. Mitochondrial dysfunction contributes to
neurodegeneration in Alzheimer disease partly through formation of reactive oxygen
species and the release of sequestered molecules that initiate programmed cell death
pathways. The heat shock proteins (HSP) are cytoprotective against a number of stressors …
c oxidase, have been reported in Alzheimer disease tissue and in cultured cells that
overexpress amyloid precursor protein. Mitochondrial dysfunction contributes to
neurodegeneration in Alzheimer disease partly through formation of reactive oxygen
species and the release of sequestered molecules that initiate programmed cell death
pathways. The heat shock proteins (HSP) are cytoprotective against a number of stressors …